Psilocybin is a psychoactive substance present in magic mushrooms, commonly ingested for recreational purposes to induce euphoria and hallucinations.
Beyond its mind-altering effects, psilocybin’s potential as a chronic pain reliever has been a subject of research.
This article features a case study that investigates the potential of microdosing mushrooms in chronic pain management.
Key Takeaways:
- Microdosing mushrooms may provide both immediate and sustained relief from pain.
- Compared to standard pain medications, microdosing psilocybin usually has fewer side effects when administered in small quantities.
- Psilocybin works with serotonin 2A (5-HT2A) receptors to alleviate pain, among other conditions.
The Study
The research, “Microdosing Psilocybin for Chronic Pain: A Case Series“, led by Dr. Matthew Lyes and his team from the Division of Pain Medicine in the Department of Anesthesiology at the University of California, San Diego, concentrated on three patients who self-administered low doses of psilocybin to control their chronic pain symptoms.
Three Patients, One Result – Chronic Pain Relief
Patient # 1
| AGE/ GENDER: | 37 Male |
| PAIN TYPE: | Neuropathic pain occurring below a spinal cord injury site. |
| PAIN INTENSITY: | Initially 4 to 5/ 10, increasing to 8/ 10 later in the day |
| PSILOCYBIN DOSE: | 250 mg of pulverized mushroom for less than 6 months |
| OUTCOME: | Discontinuation of prescribed pain medication, decreased muscle spasms, and improved bowel movement efficiency. No signs of rebound pain or withdrawal symptoms. |
| The patient expressed that unlike his regular medications that merely dulled the pain, psilocybin effectively mitigated it, lowering his average pain score from 5 to 0. | |
Case Report: Subject #2
| AGE/ GENDER: | Female, 69 years old |
| PAIN TYPE: | Complex Regional Pain Syndrome (CRPS) |
| PAIN INTENSITY: | Typically ranges from 5 to 7 out of 10, but can increase with physical activity and during episodes of pain flare-ups |
| PSILOCYBIN DOSAGE: | Regular intake of 500 mg daily for a span of 7 to 10 days with rest intervals (2 to 3 days) over a year. Dosage is increased to 750 mg to 1 gram during episodes of pain flare-ups |
| OUTCOME: | An 80% reduction in pain for 3-4 hours, gradually returning to initial levels after 12 hours. Full pain relief (90%-100%) persists for 6-8 hours, then returns to initial levels after 18 hours. |
| The patient notes a decrease in appetite without feeling nauseous. An increased dosage (750 to 1000mg) results in disorientation or instability while walking. | |
Case Report: Subject # 3
| AGE/ GENDER: | Female, 40 years old |
| PAIN TYPE: | Lumbar radiculopathy and neuropathic pain |
| PAIN INTENSITY: | 8 out of 10, increasing to full intensity (10 out of 10) during physical exertion |
| PSILOCYBIN DOSAGE: | 1000 mg from a mushroom chocolate bar consumed every two months. |
| OUTCOME: | Significant relief from pain without any psychoactive effects. An increase in flexibility and functionality is observed. Pain gradually returns to initial levels over a period of 2-4 weeks. Repeated dosing enhances control over pain. |
| The patient does not experience any significant physical, cognitive, or behavioural side effects. Her mood remains consistently stable. She maintains her regular dosage of her SSRI for depression management throughout the psilocybin treatment period. | |
Understanding Pain Management through Psilocybin
Continuous bodily and visceral pain signals strengthen certain neural pathways due to peripheral and central sensitization, resulting in chronic physical and emotional pain experiences. Psychedelics such as psilocybin activate 5-HT2A receptors, potentially resetting the brain regions related to neuropathic conditions.
A patient reported enduring pain relief for weeks. This suggests that direct stimulation of the 5-HT2A receptors might lead to a central regulation of pain perception and
Possible Side Effects: Comparing Psilocybin to Traditional Pain Killers
| PSILOCYBIN (Based on Studies) | TRADITIONAL PAIN KILLERS |
| Muscle spasms | Nausea |
| Diminished appetite | Abdominal pain |
| Confusion | Headaches |
| Unsteady gait | Addiction risk |
| No mood changes | Drowsiness |
Future Research Prospects for Psilocybin
Following their analysis of three individuals’ experiences, the research team identified several areas that could benefit from further investigation due to their potential benefits.
- Low doses of psilocybin might provide immediate and possibly enduring relief from neuropathic pain, without the risk of developing physical tolerance or addiction.
- Explore the outcomes of combining psilocybin with various treatment approaches. For example, patient #3 reported an increased pain-relief effect when psilocybin was used alongside physical therapy.
- Small doses of psilocybin may offer pain relief even in the absence of psychotherapy, as demonstrated in this case study. The team hypothesizes that incorporating therapeutic guidance could potentially enhance or prolong the therapeutic effects.
Study Limitations
Despite the encouraging findings observed in the subjects, it’s crucial to acknowledge the study’s recognized limitations.
- The limited sample size may not be a comprehensive representation of all individuals dealing with neuropathic pain.
- No subjects who were non-responsive to psilocybin were included in the study.
- There were no assessments conducted before and after treatment to gauge the effect of psilocybin on mental health conditions like depression and anxiety.
- Most of the data was self-reported by the subjects.
- The presence of the interviewer and potential biases linked to psilocybin could have influenced the participants’ responses.
- The study did not examine the potential influence of the placebo effect.
- The quantity of psilocybin present in each mushroom was not determined by the study.
Microdosing Psilocybin Mushrooms
In this analysis, both Patient #1 and Patient #2 consumed a powdered microdose of psilocybin extracted from dried mushrooms, whereas Patient #3 combined it with chocolate. There are many products available specifically for psilocybin microdosing, and we’ve gathered a list of some notable ones below.
Dried Psilocybin Mushrooms
Although the study did not mention the specific strain used, the following one is recommended for those new to this practice.
- Golden Teacher: This is one of the most prevalent and widely recognized magic mushroom strains.
- Amazonian Cubensis: This strain is known for its user-friendly nature and potential cognitive enhancements.
- Cambodian: Microdosing with Cambodian cubensis mushrooms may improve focus, societal awareness, and mood.
Microdose Capsules
- Euphoria Psychedelics – Micro Calm Capsules: This concoction contains Ashwagandha, Reishi, CBD, Valerian root, and Psilocybin Mushrooms, all of which have been scientifically shown to alleviate stress and anxiety.
- Ground Sounds – Microdose Capsules – Champion Lover: This compelling combination is available in three dosages: 50mg, 100mg, or 250mg of pure psilocybin blended with reishi, cacao, cordyceps, and maca.
- Kind Stranger – Brighten Capsules 250mg: These capsules incorporate the Golden Teacher strain, renowned for fostering clear thinking, enhanced creativity, and increased concentration.
Using Psilocybin for Pain Relief
While studies on the analgesic properties of mushrooms are still preliminary, anecdotal reports and limited case studies are offering promising results.
This emerging evidence underscores the urgency for more comprehensive research into the potential health benefits of psilocybin, class=”wp-block-list”>
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
In November 2022, the mental health company COMPASS Pathways shared the findings of their exhaustive phase 2b trial, a randomized, double-blind study. The research suggested that a single dose of psilocybin resulted in substantial reductions in depressive symptoms in comparison to a placebo. Participants given a higher 25 milligram dose displayed a lasting antidepressant response at the twelve-week follow-up.
A study published in the Psychiatry Research Journal indicated that psilocybin outperforms traditional antidepressant treatments.
How can you determine your dosage?
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
Microdosing is known to potentially enhance mood, productivity, creativity, and focus. Its most renowned benefit is its effect on mental health.
In November 2022, the mental health company COMPASS Pathways shared the findings of their exhaustive phase 2b trial, a randomized, double-blind study. The research suggested that a single dose of psilocybin resulted in substantial reductions in depressive symptoms in comparison to a placebo. Participants given a higher 25 milligram dose displayed a lasting antidepressant response at the twelve-week follow-up.
A study published in the Psychiatry Research Journal indicated that psilocybin outperforms traditional antidepressant treatments.
How can you determine your dosage?
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
Microdosing is known to potentially enhance mood, productivity, creativity, and focus. Its most renowned benefit is its effect on mental health.
In November 2022, the mental health company COMPASS Pathways shared the findings of their exhaustive phase 2b trial, a randomized, double-blind study. The research suggested that a single dose of psilocybin resulted in substantial reductions in depressive symptoms in comparison to a placebo. Participants given a higher 25 milligram dose displayed a lasting antidepressant response at the twelve-week follow-up.
A study published in the Psychiatry Research Journal indicated that psilocybin outperforms traditional antidepressant treatments.
How can you determine your dosage?
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
Furthermore, psychedelics foster connections between brain regions that usually don’t interact much. This rare connectivity is a result of psychedelics’ ability to decrease the activity of the “Default Mode Network” (DMN), which is linked to various cognitive functions like daydreaming, introspection, and dwelling on the past and future.
What is the primary benefit of microdosing mushrooms?
Microdosing is known to potentially enhance mood, productivity, creativity, and focus. Its most renowned benefit is its effect on mental health.
In November 2022, the mental health company COMPASS Pathways shared the findings of their exhaustive phase 2b trial, a randomized, double-blind study. The research suggested that a single dose of psilocybin resulted in substantial reductions in depressive symptoms in comparison to a placebo. Participants given a higher 25 milligram dose displayed a lasting antidepressant response at the twelve-week follow-up.
A study published in the Psychiatry Research Journal indicated that psilocybin outperforms traditional antidepressant treatments.
How can you determine your dosage?
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
The primary effect of psilocybin is the stimulation of a serotonin receptor, known as “5-HT2A,” in the prefrontal cortex, which leads to two main outcomes:
- The creation of “Brain-Derived Neurotrophic Factor” (BDNF)
- The enhancement of “Glutamate” transmission
Furthermore, psychedelics foster connections between brain regions that usually don’t interact much. This rare connectivity is a result of psychedelics’ ability to decrease the activity of the “Default Mode Network” (DMN), which is linked to various cognitive functions like daydreaming, introspection, and dwelling on the past and future.
What is the primary benefit of microdosing mushrooms?
Microdosing is known to potentially enhance mood, productivity, creativity, and focus. Its most renowned benefit is its effect on mental health.
In November 2022, the mental health company COMPASS Pathways shared the findings of their exhaustive phase 2b trial, a randomized, double-blind study. The research suggested that a single dose of psilocybin resulted in substantial reductions in depressive symptoms in comparison to a placebo. Participants given a higher 25 milligram dose displayed a lasting antidepressant response at the twelve-week follow-up.
A study published in the Psychiatry Research Journal indicated that psilocybin outperforms traditional antidepressant treatments.
How can you determine your dosage?
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
Chronic pain management is a specific area where the use of psilocybin has shown promise.
Despite psilocybin being yet to receive universal approval for pain relief, anecdotal evidence from case studies offers a ray of hope for those struggling with chronic pain.
Frequently Asked Questions
What effects does microdosing psilocybin produce?
The primary effect of psilocybin is the stimulation of a serotonin receptor, known as “5-HT2A,” in the prefrontal cortex, which leads to two main outcomes:
- The creation of “Brain-Derived Neurotrophic Factor” (BDNF)
- The enhancement of “Glutamate” transmission
Furthermore, psychedelics foster connections between brain regions that usually don’t interact much. This rare connectivity is a result of psychedelics’ ability to decrease the activity of the “Default Mode Network” (DMN), which is linked to various cognitive functions like daydreaming, introspection, and dwelling on the past and future.
What is the primary benefit of microdosing mushrooms?
Microdosing is known to potentially enhance mood, productivity, creativity, and focus. Its most renowned benefit is its effect on mental health.
In November 2022, the mental health company COMPASS Pathways shared the findings of their exhaustive phase 2b trial, a randomized, double-blind study. The research suggested that a single dose of psilocybin resulted in substantial reductions in depressive symptoms in comparison to a placebo. Participants given a higher 25 milligram dose displayed a lasting antidepressant response at the twelve-week follow-up.
A study published in the Psychiatry Research Journal indicated that psilocybin outperforms traditional antidepressant treatments.
How can you determine your dosage?
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
Chronic pain management is a specific area where the use of psilocybin has shown promise.
Despite psilocybin being yet to receive universal approval for pain relief, anecdotal evidence from case studies offers a ray of hope for those struggling with chronic pain.
Frequently Asked Questions
What effects does microdosing psilocybin produce?
The primary effect of psilocybin is the stimulation of a serotonin receptor, known as “5-HT2A,” in the prefrontal cortex, which leads to two main outcomes:
- The creation of “Brain-Derived Neurotrophic Factor” (BDNF)
- The enhancement of “Glutamate” transmission
Furthermore, psychedelics foster connections between brain regions that usually don’t interact much. This rare connectivity is a result of psychedelics’ ability to decrease the activity of the “Default Mode Network” (DMN), which is linked to various cognitive functions like daydreaming, introspection, and dwelling on the past and future.
What is the primary benefit of microdosing mushrooms?
Microdosing is known to potentially enhance mood, productivity, creativity, and focus. Its most renowned benefit is its effect on mental health.
In November 2022, the mental health company COMPASS Pathways shared the findings of their exhaustive phase 2b trial, a randomized, double-blind study. The research suggested that a single dose of psilocybin resulted in substantial reductions in depressive symptoms in comparison to a placebo. Participants given a higher 25 milligram dose displayed a lasting antidepressant response at the twelve-week follow-up.
A study published in the Psychiatry Research Journal indicated that psilocybin outperforms traditional antidepressant treatments.
How can you determine your dosage?
On the first day, start with a 0.1-gram dosage of psilocybin mushrooms. If the effects are not as desired, you can gradually increase your dosage by 0.05 grams on subsequent microdosing days until you find your ideal dosage.
Those with a history of psychotropic drug use may require a higher dosage, up to 0.5 grams, to achieve the desired effects.
What precautions should be taken before consuming mushrooms?
class=”wp-block-list”>What’s the suggested frequency for mushroom microdosing?
There are several well-accepted protocols that suggest structured schedules for psychedelic microdosing. The main differences among these protocols lie in the number of “off” days included, which are the days when you abstain from microdosing.
The commonly suggested protocols advise having 1-3 rest days between microdoses to align with the body’s natural tolerance mechanisms. The three protocols being considered here include the Fadiman Protocol, the Stamets Stack, and intuitive microdosing.
